Why do words “sober” me up and I lose my buzz?

I’m not sure if I’m explaining this right, but does anyone else ever have a conversation with someone and what they say makes you feel like you’ve lost your buzz?

A number of times in the past, I’ll have a nice buzz going on, and someone will say something that makes me sad or upset (unrelated to me drinking) and then all of a sudden, I feel less buzzed.

One I can recall is that I was having a fun time at a family wedding in 2017 and one of my family members made an indirect comment towards me. I don’t think they realized that it had hurt my feelings or that it was said intentionally, but then my buzz left and I was depressed the rest of the evening. And the one part that makes me feel even worse is that I was so depressed, that and older (like 80s) family member (not directly related to me) asked if I wanted to dance. I politely declined and he passed away I think within the year. I would have otherwise.

And the comment that put me in that mood still affects me today.

This is just one example, but it does happen quite a bit.