Has anyone thought about using chemical drugs to fix Asian flush / ALDH2 deficiency / alcohol intolerance？

In fact, we’ve been looking for more advanced solutions to Asian flush for quite some time, compared with the currently popular approach of using antihistamines (Pepcid AC / famotidine) to mask the visible vasodilation. We’ve read a large number of papers on ALDH2 and its activators on Google Scholar, and then did actual self-testing. So far, our findings are:

–alda-1 (first-generation activator): because of its chemical properties, the oral effect is extremely poor. If trying to improve it with a drug delivery method like a self-microemulsifying formulation, the vehicle itself will affect acetaldehyde metabolism.

–Mirivadelgat / FP-045 (novel activator): it has very high oral bioavailability, and its safety is supported. In our tests it showed ideal effects even at small doses. But this drug is not on the market yet, and obtaining it on our own is very expensive, so we’re still looking for ways to deal with that.

–Magnolol (natural activator): it has poor bioavailability by itself and also needs an optimized delivery method, and the papers say you need a very high dose to reach the effective concentration, so this needs further consideration.

–d-limonene (ALDH3A1 natural activator): it improves metabolic capacity through a bypass pathway, since it doesn’t directly activate ALDH2. In our actual tests the effect was very small.

-Some existing supplements (sunset / essential AD2): these supplements contain many protective components, but their effects are definitely weaker than the compounds above.

-Traditional solutions: NAC, DHM, Pepcid AC, etc. The first two have some effect but the flushing is still obvious. Pepcid AC can basically keep the flushing within an acceptable range — but this is only the surface; acetaldehyde still cannot be metabolized normally.

This may be a bit niche or strange, but we noticed that as early as 2007 there were already people on some forums discussing alda-1, so we feel there should be people now who are doing, or at least thinking about, the same things as we are. Possible directions at this point include: alda-1 variants optimized by some Asian teams with improved oral bioavailability, some reported natural activators (such as baicalin), or existing approved drugs that have been shown to target ALDH2.

Everything above is absolutely real and not generated by AI. If anyone has any findings or suggestions, or have experience in biology and chemistry, please share.